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KMID : 0617320000090010171
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Journal of Pharmacetical Sceiences Ewha Womans University
2000 Volume.9 No. 1 p.171 ~ p.178
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Synthesis of (-)-Neplanocin A Analogues as Potential Antiviral Agents
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Shin, Dae Hong
Lee, Hyuk Woo/Park, Sung Soo/Kim, Joong Hyup/Jeong, Lak Shin/Chun, Moon Woo
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Abstract
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Based on (-)-neplanocin A with the 5´-hydroxyl substituted with fluoro, azido, or amino group, the corresponding xylo- and arabino derivatives were synthesized from D-ribose using the Mitsunobu reaction as a key step. None of the final nucleosides did show either significant antiviral activities or cytotoxicities.
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